PSV Eindhoven face a mountain to climb ahead of the second-leg as they welcome Sevilla to the Philips Stadion chasing a three-goal deficit to keep themselves in the competition.
Ruud van Nistelrooy saw his side lose 3-0 in Sevilla against La Liga opposition with goals from striker Youssef En-Nesri, winger Lucas Ocampos and defender Nemanja Gudelj as the Spanish side arrive in Eindhoven with a comfortable advantage.
Despite this lead, Jorge Sampaoli’s side have been struggling in La Liga this season and find themselves 12th in the league table but have picked up three wins in their last five matches – which is half of their wins in the league this season.
The visitors are 16 points from a European spot in the league but are only three points above the relegation zone which could turn at any moment if they do not maintain their current domestic form.
Here is the form from both sides in all competitions:
Van Nistelrooy is expected to make changes to his starting XI with Johan Bakayoko in line to start on the flank while Thorgan Hazard tries to shake off a muscle issue.
Defender Phillipp Mwene could return to the side while Xavi Simons may switch to play behind Luuk de Jong in the clash and Anwar El Ghazi remains a doubt for this match.
Sevilla will be unable to call upon Erik Lamela after the playmaker collected his third European caution of the season in the first-leg.
Defender Loic Bade, on loan from Rennes, will be out with an arm injury while Fernando could feature in the back three but Gudelj does return to the side after serving a domestic suspension at the weekend.